GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3796352 | 1 | rs6445557 | chr3:53083969 | RFT1 | chr3:53122503-53164470:- | -0.59 | -7.99 | 1.0E-14 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs1031925 | 1 | rs6445622 | chr3:51356823 | HEMK1 | chr3:50606583-50622419:+ | 0.2 | 4.18 | 3.4E-5 | Melanoma |
| THCA | cis | rs1031925 | 1 | rs6445622 | chr3:51356823 | TEX264 | chr3:51705222-51738338:+ | -0.22 | -6.05 | 2.93E-9 | Melanoma |
| THCA | cis | rs7647973 | 1 | rs6446262 | chr3:49401153 | GMPPB | chr3:49758932-49761384:- | -0.17 | -3.73 | 0.000218 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446262 | chr3:49401153 | P4HTM | chr3:49027341-49044579:+ | 0.19 | 4.65 | 4.33E-6 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446268 | chr3:49445695 | CCDC51 | chr3:48473582-48481529:- | -0.15 | -3.59 | 0.00037 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446268 | chr3:49445695 | GMPPB | chr3:49758932-49761384:- | 0.17 | 3.85 | 0.000133 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446268 | chr3:49445695 | P4HTM | chr3:49027341-49044579:+ | -0.16 | -3.99 | 7.6E-5 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446268 | chr3:49445695 | WDR6 | chr3:49044637-49053386:+ | 0.19 | 3.88 | 0.000121 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446275 | chr3:49466871 | GMPPB | chr3:49758932-49761384:- | 0.16 | 3.72 | 0.000221 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446275 | chr3:49466871 | P4HTM | chr3:49027341-49044579:+ | -0.17 | -4.27 | 2.36E-5 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6446275 | chr3:49466871 | WDR6 | chr3:49044637-49053386:+ | 0.18 | 3.69 | 0.000251 | Menarche (age at onset) |
| THCA | cis | rs7438704 | 1 | rs6447634 | chr4:48413511 | OCIAD1 | chr4:48833015-48863831:+ | -0.14 | -4.21 | 3.0E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs6447650 | 1 | rs6447650 | chr4:40381210 | CHRNA9 | chr4:40337469-40356973:+ | 0.32 | 3.36 | 0.000848 | Body mass index (change over time) |
| THCA | cis | rs1949733 | 1 | rs6447875 | chr4:8503206 | C4orf23 | chr4:8440604-8495258:+ | -0.35 | -7.43 | 5.08E-13 | Response to antineoplastic agents |